Estrogen receptor-related receptor (ERR gamma), a NR3 Steroid Receptor, has been suggested to affect differentiation of the brain, heart, and kidney.
ERR gamma binds as a monomer to an extended half-site of the ERRE type (TCAAGGTCA).
ERR gamma has been shown to interact with PGC-1 alpha and has been implicated in the regulation of mitochondrial energy metabolism.
In humans, ERR gamma pre-mRNA undergoes extensive alternative splicing at the 5' end, yielding at least six mRNA splice variants and two protein isoforms that differ by 23aa in the N terminus.
ERR gamma has been shown to be overexpressed in breast tumors, and its expression is correlated with levels of ErbB4, a likely indicator of preferred clinical course.
As a result, ERR gamma has been suggested to be a potential biomarker for favorable clinical course and, possibly, hormonal sensitivity, and as a candidate target for therapeutic development.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human ESRRG/ERR3. Species Crossreactivity: bovine, canine, hamster, equine, monkey, mouse, rabbit, rat, bat, gorilla, orangutan, gibbon
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Bo Ca Eq Hm Hu Mk Mo Rb Rt
Immunogen：Synthetic peptide corresponding to 14aa from the N-terminus of human ESRRG/ERR3. Species sequence homology: chicken and xenopus.
