Estrogen-related receptor beta (ERR beta) a NR3 Steroid Receptor, has been shown to affect early placental development.
ERR beta also can act as a repressor of transcriptional activity mediated by the glucocorticoid receptor (GR).
ERR beta binds as a monomer to the extended half-site TNAAGTGCA and as a homodimer to the estrogen response element (ERE), palindromic thyroid hormone response element (TRE(pal)), and SF-1 response element, but not to the glucocorticoid response element (GRE).
ERR beta mutations lead to abnormal development of the chorion and defective diploid trophoblast proliferation, and are lethal during midgestation.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 1ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human ESRRB/ERR Beta. Species Crossreactivity: monkey, equine, gorilla
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Eq Hu Mk
Immunogen：Synthetic peptide corresponding to 16aa from the N-terminus of human ESRRB/ERR Beta. Species sequence homology: mouse and rat.
