The Endothelin Receptor ETB is expressed in most tissues.
Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss.
The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system.
Applications:Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 4-11ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human Endothelin B Receptor. Species crossreactivity: canine
Isotype：IgG
Calc Applications Abbrev：IC IHC WB
Calc Crossreactivity：Ca Hu
Immunogen：Synthetic peptide corresponding to 19aa from the N-terminus of human EDNRB. Species sequence homology: gorilla and gibbon.
