DDR1 is activated by various types of collagen, including types I through IV.
Binding of collagen to DDR1 protein results in autophosphorylation and a delayed but sustained tyrosine kinase activation.
DDR1 may function in cell-to-cell interaction or recognition.
At least three mRNA variants, resulting in different protein isoforms of 875, 913 and 919aa, have been reported.
DDR1 protein has been shown to be over expressed in human breast, ovarian, esophageal and pediatric brain tumors.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 6ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human DDR1. Species Crossreactivity: chimpanzee, gorilla, gibbon, monkey, porcine
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu Mk Po
Immunogen：Synthetic peptide corresponding to 16aa from the internal region of human DDR1. Species sequence homology: bovine, canine, hamster, equine, monkey, mouse and rat.
