CXCR4, a Chemokine Receptor involved in organ vascularization, neuronal cell migration, and patterning of the central nervous system during development.
It binds stromal cell-derived factor 1 (SDF1, also called PBFS) and mediates migration of resting leukocytes and is unique in homing hematopoietic progenitors to bone marrow.
These properties suggest that CXCR4 is involved in tumor cell migration and local tumor invasion.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 9-14ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human CXCR4. Species crossreactivity: chimpanzee, gorilla, orangutan, gibbon, monkey, mouse, rat, hamster, rabbit and chicken.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Ch Hm Hu Mk Mo Rb Rt
Immunogen：Synthetic peptide corresponding to 20aa from 3rd cytoplasmic domain of human CXCR4.
