Muscarinic cholinergic receptor 2, an Acetylcholine Receptor, has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release.
The M2 receptor has also been suggested to mediate smooth muscle contractility.
Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain.
Increase in M2 receptor heterozygosity has been associated with depression in women.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 4-8ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human CHRM2. Species Crossreactivity: gibbon, chimpanzee, gorilla and orangutan.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to 19aa from 3rd cytoplasmic domain of human CHRM2. Species sequence homology: canine, hamster, monkey, porcine and rat.
