Also known as CRKRS, the protein has an arginine/serine-rich (RS) domain that is found predominantly in splicing factors, and extensive proline-rich regions that match the consensus for SH3 and WW domain binding sites.
Anti-CrkRS immunoprecipitates have been shown to phosphorylate the C-terminal domain of RNA polymerase II in vitro.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 6ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human CDK12/CRKRS. Species crossreactivity: gibbon, canine, gorilla and monkey.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Ca Hu Mk
Immunogen：Synthetic peptide corresponding to 20aa from the internal region of human CDK12/CRKRS. Species sequence homology: rat, bat, bovine and rabbit.
