Calcitonin receptor-like receptor (CRLR) is an Adrenomedullin Receptor that requires two additional proteins to function: a chaperone protein RAMP (receptor activity modifying protein) and the component protein RCP.
The function of CRLR depends on its interaction with RAMP.
When coexpressed with RAMP1, CRLR acts as a receptor for calcitonin gene-related peptide (CGRP).
In contrast, when CRLR is coexpressed with either RAMP2 or RAMP3, it acts as a receptor for adrenomedullin.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 34ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human CALCRL. Species crossreactivity: monkey, gorilla, rat, bovine, canine, gibbon, goat, hamster, equine, porcine, rabbit, xenopus, orangutan
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Bo Ca Eq Gt Hm Hu Mk Po Rb Rt Xe
Immunogen：Synthetic peptide corresponding to 16aa from 3rd cytoplasmic domain of human CALCRL. Species sequence homology: mouse, bat, guinea pig and zebrafish.
