CASR, a Calcium-Sensing Receptor, functions as a sensor in parathyroid and kidney to determine extracellular calcium concentration and to maintain calcium homeostasis.
This receptor regulates both secretion of parathyroid hormone and excretion of urinary calcium.
Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, which is also correlated with hyperparathyroidism.
On the other hand, mutations that activate CASR cause autosomal dominant hypocalcemia.
Hjalm et al.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 4-8ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human Calcium Sensing Receptor. Species Crossreactivity: bat, gibbon, bovine, chicken, canine, gorilla, hamster, equine, monkey, mouse, porcine, rabbit and rat.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Bo Ca Ch Eq Hm Hu Mk Mo Po Rb Rt
Immunogen：Synthetic peptide corresponding to 17aa from the N-terminus of human Calcium Sensing Receptor. Species sequence homology: xenopus.
