ALK7, a Activin/TGFb type protein kinase, is a member of the Nodal signaling pathway, which is implicated in developmental events such as mesoderm formation and left-right axis specification.
ALK7 is a type I receptor that has been shown to collaborate with activin receptor type 2B (ActRIIB).
A constitutively active form of ALK7 has been shown to increase phosphorylation of Smad2, a receptor-regulated signaling protein which translocate to the nucleus to activate transcription.
Smad3 also is believed to be a target of ALK7.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human ALK7/ACVR1C. Species Crossreactivity: bovine, porcine, bat, gibbon, gorilla
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Bo Hu Po
Immunogen：Synthetic peptide corresponding to 16aa from the internal region of human ALK7/ACVR1C. Species sequence homology: equine, monkey and rabbit.
