Desmin is a 53kD intermediate filament protein and exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle).
Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development and muscle cell differentiation.
In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk.
The expression pattern of desmin in smooth muscle is much more heterogenous.
Coexpression of desmin and vimentin has been observed in tumors derived from muscle tissue, i.e.
rhabdomyosarcomas and leiomyosarcomas.
Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
With avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：250ul
Host：rabbit
Source Antibody：chicken
Grade：Purified
Purity：Purified
Form：Supplied as a liquid in 0.09% sodium azide.
Specificity：Recognizes Desmin K5. Reacts exclusively with desmin, which is expressed in smooth and striated muscle cells and their tumors. Species Crossreactivity: Bovine, chicken, goat, hamster, human, mouse, rat, zebrafish.
