84-2135-97　Scyth (Bat3, Large Proline-rich Protein BAG6, BAG Family Molecular Chaperone Regulator 6, BCL2-associated Athanogene 6, BAG-6, BAG6, HLA-B-associated Transcript 3, Protein Scythe, Bag6) [KO Validated] 100ul　168498

特徴

• Scythe protein (also known as BAT3 and HLA-B-associated transcript 3) is an apoptotic regulator that is highly conserved in eukaryotes and contains a ubiquitin-like domain near its N-terminal.
• It binds Reaper, a potent apoptotic inducer, as well as Hid and Grim.
• Scythe and Reaper are thought to signal apoptosis, in part through regulating the folding and activity of apoptotic signaling molecules.
• Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosis.
• It interacts with transforming growth factor-b (TGF-b) receptors and enhances TGF-b1-induced type I collagen expression in mesangial cells.
• With SET1A, Scythe forms a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression.
• Scythe is essential for p300-mediated acetylation of p53.
• Scythe/BAT3 is identified as a critical regulator of hsp70-2 in spermatogenesis, thereby providing a possible molecular target in idiopathic male infertility.
• The human Scythe/BAT3 ortholog in rodents is predominantly and developmentally expressed in testis.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:5000-1:8000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.