84-2135-80　RFFL (RING Finger and FYVE-like Domain-containing Protein 1, E3 Ubiquitin-protein Ligase Rififylin, Caspase Regulator CARP2, Caspases-8 and -10-associated RING Finger Protein 2, CARP2, CARP-2, FYVE-RING Finger Protein Sakura, Fring, RING Finger Protein 189, RNF189, RING Finger Protein 34-like, RNF34L) 500ug　168479

特徴

• RFFL, also known as rififylin, RING finger and FYVE-like domain-containing protein 1, FYVE-RING finger protein, sakura, fring, caspases-8 and -10-associated RING finger protein 2, CARP-2, caspase regulator CARP2, RING finger protein 189 and RING finger protein 34-like, is a novel modulator of NF-kB activation.
• RFFL possesses E3 ubiquitin protein ligase activity and has been shown to regulate the levels of CASP8 and CASP10 by targeting them for proteasomal degradation.
• RFFL also possesses apoptotic activity and may bind phosphatidylinositol phosphates.
• RFFL is a membrane bound cytoplasmic protein that is expressed ubiquitously.
• RFFL can be detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes and is rapidly degraded after stimulation with TNFSF10, and probably by caspases.
• Multiple transcript variants have been detected for this protein.
• Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:4,000-1:20,000Western Blot: 1:500-1:3000Immunohistochemistry: 1:500-1:3000Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile dH2O or PBS.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.