This gene (PTENP1)is a highly homologous pseudogene of PTEN.
PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency.
PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase.
It contains a tension like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases.
Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates.
It negatively regulates intracellular levels of phosphatidylinositol- 3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:160,000Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in 0.02M potassium phosphate, 0.15M sodium chloride, pH 7.2, 0.01% sodium azide.
Specificity：Recognizes human PTEN-P1.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Rb
Immunogen：Synthetic peptide corresponding to human PTEN-P1 at N-terminus.
