The product of the PARK7 gene, known as PARK7, Parkinson disease (autosomal recessive, early onset) 7, DJ-1 mutant, and DJ-1 oncogene product, functions as a positive regulator of androgen receptor-dependent transcription.
PARK7 may also function as a redox-sensitive chaperone and as a sensor for oxidative stress and also has been reported to prevent aggregation of SNCA.
PARK7 protects neurons against oxidative stress and cell death and plays a role in fertilization.
While PARK7 has no proteolytic activity, it does have a weak transforming activity.
PARK7 forms a homodimer and binds to DJBP and PIAS2.
PARK7 is part of a ternary complex containing PARK7, DJBP and AR and shows both a nuclear and cytoplasmic localization.
In some cells, PARK7 is associated with mitochondria.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:10,000-1:50,000Western Blot: 1:500-1:2000Immunohistochemistry: 2mg/ml-5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in 0.02M potassium phosphate, 0.15M sodium chloride, pH 7.2, 0.01% sodium azide.
Specificity：Recognizes human PARK7. Species Crossreactivity: chimpanzee, african green monkey and zebrafish.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Mk Ze
Immunogen：Synthetic peptide corresponding to aa177-189 from human PARK7.
