84-2135-25　p47 ING3 (Inhibitor of growth family member 3, Inhibitor of growth protein 3) 100ug　168412

特徴

• p47 ING3 is a tumor suppressor protein similar to ING1 that can interact with TP53, inhibit cell growth, and induce apoptosis.
• This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling.
• This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax.
• Over-expression of this gene has been shown to inhibit cell growth and induce apoptosis.
• Allelic loss and reduced expression of this gene were detected in head and neck cancers.
• Multiple alternatively spliced transcript variants have been observed.
• The accession number listed below is for variant that encodes the longest isoform.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:10,000-1:40,000Western Blot: 1:200-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.