84-2135-09 NKIP1 (iASSP, inhibitor of apoptosis stimulating protein of p53, Inhibitor of ASPP protein, NFkB interacting protein 1, PPP1R13B-like protein) 100ug 168394
84-2135-09 NKIP1 (iASSP, inhibitor of apoptosis stimulating protein of p53, Inhibitor of ASPP protein, NFkB interacting protein 1, PPP1R13B-like protein) 100ug 168394
ASPP proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins.
ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis.
In contrast, the third member, iASPP, functionally inactivates p53.
iASPP (also called protein phosphatase 1 regulatory (inhibitor) subunit 13 like protein, Inhibitor of ASPP protein, Protein iASPP, PPP1R13B-like protein and NFkB-interacting protein 1) plays a central role in regulation of apoptosis and transcription via its interaction with NF-k-B and p53/TP53 proteins.
iASPP blocks transcription of HIV-1 virus by inhibiting the action of both NF-k-B and SP1.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:40,000-1:160,000Western Blot: 1:1000-1:5000Immunohistochemistry: 1:1000-1:5000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in 0.02M potassium phosphate, 0.15M sodium chloride, pH 7.2, 0.01% sodium azide.
Specificity：Recognizes human iASSP.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa780-797 from human iASPP (isoform 1).
