84-2133-80　Histone H2AvD PS137 (H2AvD protein) (Drosophila) 100ug　168244

特徴

• Variant histones H2A are synthesized throughout the cell cycle and are very different from classical S-phase regulated H2A.
• H2AvD is vital for viability, but the exact function of variant histones H2A is not known.
• H2A is a core component of the nucleosome, an octamer containing two molecules each of H2A, H2B, H3 and H4.
• The octamer wraps approximately 146 bp of DNA.
• HsAvD is expressed both maternally and zygotically and is found in embryos through to adults (female only).
• The human homologue, H2AX, is phosphorylated by ATM protein kinase when double strand DNA breaks occur.
• In mouse, H2AX ''knock out'' mice have an increased incidence of cancer.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:4000-1:16,000Western Blot: 1:400-1:1600Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.