84-2133-75　HAUS8 (HICE1, HAUS Augmin-like Complex Subunit 8, HEC1/NDC80-interacting Centrosome-associated Protein 1, Sarcoma Antigen NY-SAR-48, MGC20533) 100ul　168235

特徴

• Hice1 contributes to the mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
• Normal bipolar spindle formation is critical for accurate chromosome segregation and proper mitotic progression.
• Failure in this event leads to spindle checkpoint activation and chromosome missegregation that ultimately leads to aneuploidy.
• Hice1 binds to microtubules directly, and promotes spindle integrity and chromosome stability.
• Hice1 has also shown to play an important role in targeting the ?TuRC complex to the mitotic spindle, a step that appears to be required for spindle-mediated microtubule generation and normal chromosome segregation.
• The HAUS augmin-like complex's interaction with microtubules is strong during mitosis, while it is weak or absent during interphase.
• During interphase, it is primarily cytoplasmic, associating with centrosomes and with the mitotic spindles, preferentially at the spindle pole vicinity.
• During anaphase and telophase, it additionally associates with the spindle midzone and midbody, respectively.
• Further characterization of the function of Hice1 will likely be important for better understanding the mechanism of normal mitotic progression and high fidelity chromosome segregation.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:250,000Western Blot: 1:10,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.