FANCC (also called Protein FACC or Fanconi anemia group C protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function.
FANCC may also be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
FANCC belongs to the multi-subunit Fanconi anemia (FA) complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM.
FANCC is mainly found within the nucleus although some protein is localized in the cytoplasm.
This protein is ubiquitously expressed.
Defects in FANCC are a cause of Fanconi anemia (FA).
FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopaenia, a diverse assortment of congenital malformations.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:20,000-1:80,000Western Blot: 1:1000-1:3000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A/G affinity chromatography.
Form：Supplied as a liquid in 0.02M potassium phosphate, 0.15M sodium chloride, pH 7.2, 0.01% sodium azide.
Specificity：Recognizes human FANCC. Species Crossreactivity: chimpanzee.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa96-112 from human FANCC.
