84-2132-65　Cenexin-1 (ODF84, Outer dense fiber of sperm tail 2, Cenexin1 variant 1, KKT 4) 100ug　168095

特徴

• Cenexin-1 (ODF84) and cenexin-2 are splicing variants that are expressed from the same genetic locus outer dense fiber protein 2 (ODF2).
• Cenexin-1 and cenexin-2, regarded as centriolar proteins.
• Cenexin-1, a 93kD variant of ODF2, is the major form of cennexin expressed in various somatic cells and tissues and associates with centrosomes.
• Cenexin-1 contains a unique C-terminal extension that appears to play a critical role in recruiting mitotic regulators such as polo-like kinase 1.
• In contrast, ODF2, a 70kD protein, is a major component of sperm tail cytoskeleton and abundantly expressed in testis.
• Additional evidence suggests that both of these proteins play important role in primary cilia formation.
• The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation.
• Defects in the outer dense fibers lead to abnormal sperm morphology and infertility.
• Cenexin-1 is one of the major outer dense fiber proteins.
• Multiple protein isoforms are encoded by transcript variants of the cenexin gene; however, not all isoforms and variants have been fully described.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:500-1:10,000Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.