84-2132-15　ASAP3 (DDEFL1, UPLC1, Arf-GAP with SH3 Domain, ANK Repeat and PH Domain-containing Protein 3, Development and Differentiation-enhancing Factor-like 1, Protein Up-regulated in Liver Cancer 1) 100ug　168037

特徴

• UPLC1 (up-regulated in liver cancer 1)/ASAP3, also named DDEFL1 (development and differentiation-enhancing factor-like 1) or ASAP3, is a member of the AZAP family of proteins.
• These proteins catalyze the hydrolysis of GTP bound to ADP-ribosylation factor (Arf) proteins, thereby causing Arf inactivation.
• For this reason, the ASAPs are generally called ArfGAPs.
• The activity of ArfGAPs is dependent on the presence of phosphoinositides and is implicated in cellular processes such as membrane trafficking and remodeling of the actin cytoskeleton.
• ASAP3 has been found to be up-regulated in 80% of the hepatocellular carcinomas examined.
• Initial biochemical characterization reveals that ASAP3 shows class-specific GAP activity on Arf proteins, preferring Arf5 over Arf1 and Arf6.
• ASAP3 has beed developed through the NCI collaboration program and is ideal for Cancer and Signal Transduction research.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: :1000-1:10,000Western Blot: 1:200-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.