ABCB5 is a novel member of the human P-glycoprotein family.
It functions as a determinant of membrane potential and regulator of cell fusion in physiologic skin progenitor cells.
Cell fusion is thought to contribute to tissue differentiation.
ABCB5 is predominantly expressed in melanoma cells and is a novel molecular marker for a distinct subset of chemoresistant stem cell phenotype-expressing tumor cells among human epidermal melanocytes.
ABCB5 is a rhodamine efflux transporter.
This product is intended to be used to confirm cellular localization and expression level of ABCB5.
ABCB5 is ideal for Cancer and Signal Transduction research.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:10,000-1:50,000Western Blot: 1:20,000Immunohistochemistry: 1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in 0.02M potassium phosphate, 0.15M sodium chloride, pH 7.2, 0.01% sodium azide.
Specificity：Recognizes human ABCB5.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Rb
Immunogen：Synthetic peptide corresponding to an internal region of human ABCB5.
