84-2131-76　Protocadherin-17 (PCDH17, PCDH68, PCH68) 100ug　167691

特徴

• Protocadherin 17 (PCDH-17) is a 120-150kD glycoprotein, d2-group member of the of the protocadherin subfamily, cadherin family of molecules.
• It is expressed on endothelium and epithelium such as stratified squamous epithelium and (likely) gastric columnar epithelium.
• PCDH17 is posited to act as an adhesion molecule, and appears to play a role in promoting cell cycle arrest and inhibiting migration.
• Mature human PCDH-17 is a type I transmembrane protein that is 1142aa in length.
• It contains a 690aa extracellular domain (ECD) (aa18-707) plus a 431aa cytoplasmic region.
• There are 6 cadherin domains in the ECD (aa18­695).
• Two splice forms are reported that involve substitutions in the cytoplasmic region.
• The first possesses a 14aa substitution, while the second shows a 25aa substitution, both for aa876-1159.
• Over aa18-705, human PCDH-17 shares aa98% identity with mouse PCDH-17.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile PBS.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.