84-2131-61　ZNRF1 (E3 ubiquitin-Protein ligase, MGC101991, nerve injury-induced gene 283 Protein, nin283, peripheral nerve injury Protein nin283, ring finger Protein 42, Rnf42, zinc and ring finger 1, zinc ring finger Protein 1, zinc/RING finger Protein 1, Znrf1, Zrfp1) 100ug　167542

特徴

• E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation.
• Plays a role in the establishment and maintenance of neuronal transmission and plasticity.
• Regulates Schwann cells differentiation by mediating ubiquitination of GLUL.
• Promotes Wallerian degeneration, a neurodegeneration disorder, by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:32,000Western Blot: 1-3ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.