Acts as a sequence specific DNA binding transcriptional activator or repressor.
The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity.
May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
Involved in Notch signaling by probably inducing JAG1 and JAG2.
Activates transcription of the p21 promoter By similarity.
Activates RIPK4 transcription.
Plays a role in the regulation of epithelial morphogenesis.
The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm.
Required for limb formation from the apical ectodermal ridge.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:Peotide ELISA: 1:64,000Western Blot: 0.3-1ug/ml detects a band at ~75kD in lysates of cell line A431Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes human Trp63. Expeceted to recognize reported isoforms d, e, f, g, h.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Peptide corresponding to aa ENNAQTQFSEPQYC from the N-terminus of human TRP63 (NP_035771.1, NP_001120736.1, NP_001120734.1, NP_001120735.1, NP_001120737.1). Species sequence homology: mouse, rat, canine, porcine
