Mediates homophilic cell-cell adhesion in a Ca2+-independent manner.
Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner.
Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells.
Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.
May contribute to the less invasive phenotypes of lepidic growth tumor cells.
In mast cells, may mediate attachment to and promote communication with nerves.
CADM1, together with MITF, is essential for development and survival of mast cells in vivo.
May act as a synaptic cell adhesion molecule that drives synapse assembly.
May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons.
May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:128,000Western Blot: 1-3ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Purified
Purity：Purified by ammonium sulfate precipitation.
Form：Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes human CADM1. Species sequence homology: Bovine, canine, mouse, rat.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo
Immunogen：Peptide with sequence C-NLQTQRYLEVQ, from the internal region of the protein sequence (NP_055148.3, NP_001091987.1).
