84-2129-21　［取扱停止］STK11IP (Serine/Threonine-protein Kinase 11-interacting Protein, LKB1-interacting Protein 1, KIAA1898, LIP1, LKB1IP, STK11IP1) 100ug　151492

特徴

• LKB1 (also STK11 and JBS) is a 55kD member of the CAMK Ser/Thr protein kinase family.
• It is ubiquitously expressed, and considered to be a tumor suppressor.
• LKB1 is both nuclear and cytoplasmic, and appears to contribute to cell polarization, G1 cell cycle arrest and Wnt signaling.
• It is known to complex with STRAD and CAB39/MO25, and phosphorylate PTEN plus p53.
• Human LKB1 is 433aa in length.
• It contains a protein kinase domain (aa49-309) and a prenylation motif (CysLysGlnGln) over aa430-433.
• There are two potential isoforms of LKB1.
• One shows a nine aa insertion after Tyr126, while another shows a 34 aa substitution for aa371-433.
• Over aa242-433, human and mouse LKB1 are identical in aa sequence.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:64,000Western Blot: 0.3-1ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Human Ovary Tissue Lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.