84-2123-51　［取扱停止］PACSIN3 (Protein Kinase C And Casein Kinase Substrate In Neurons Protein 3, SH3 Domain-containing Protein 6511, Endophilin I, FLJ17861, SDPIII) 100ug　150764

特徴

• A member of the Endophilin family, Endophilin A1 is a protein containing SH3 domains, and has been implicated in the trafficking of clathrin-mediated synaptic vesicle endocytosis within the membrane.
• It was originally characterized as a presynaptically enriched protein that binds to endocytic proteins polyphosphoinositide synaptojanin and dynamin.
• Endophilin A1 has been implicated in endocytic vesicle budding when its function in cell-free systems and in living synapses has been disturbed.
• Along with the SH3 domain, Endophilin A1 contains a BAR domain in the N-terminal region, that has been found to induce and bind membrane curvature.
• This protein's expression is localized to the brain, most specifically in the frontal cortex.
• Markedly high expression is observed in fetal cerebellum.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:16,000Western Blot: 1-3ug/mLOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.