Forkhead box protein P2 (FoxP2) is a multidomain transcriptional repressor that belongs to the Fox family of proteins.
The FoxP2 protein contains a forkhead-box DNA-binding domain, characteristic of the FOX group of transcription factors.
In addition, this protein contains a polyglutamine tract, as well as zinc finger and leucine zipper motifs.
In order for FoxP2 to bind DNA, it forms homodimers and heterodimers with FoxP1 and FoxP4.
The forkhead box family of proteins play an important role in immune response, organ development and the development of cancer.
Functional studies in vertebrates suggest this with this gene plays a role in the modulation neural plasticity.
In line with these findings, mutations of FoxP2 in humans have been linked to speech and language disorders.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:32,000Western Blot: 0.5-1.5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes human FOXP2.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to 13aa from near the C-terminus of FOXP2. Species sequence homology: mouse, rat, canine, bovine and porcine.
