This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family .
The protein is enriched in the heterochromatin and associated with centromeres.
The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins.
The protein may play an important role in the epigenetic control of chromatin structure and gene expression.
Several related pseudogenes are located on chromosomes 1, 3, and X.
Multiple alternatively spliced variants, encoding the same protein, have been identified.
[provided by RefSeq].
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:32,000Western Blot: 0.3-1ug/mlImmunohistochemistry (Formalin fixed paraffin embedded): 2-3ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:A431 Cell Lysate
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes human CBX1.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to 13aa from near the internal region of CBX1. Species sequence homology: mouse, rat, canine and bovine.
