84-2113-67　［取扱停止］RBBP8 (DNA Endonuclease RBBP8, CtBP-interacting Protein, CtIP, Retinoblastoma-binding Protein 8, RBBP-8, Retinoblastoma-interacting Protein and Myosin-like, RIM, Sporulation in the Absence of SPO11 Protein 2 Homolog, SAE2, CTIP) 100ug　146661

特徴

• RBBP8, also known as CtBP (carboxy-terminal binding protein) interacting protein (CTIP), was characterized for its role in transcription as a cofactor for the transcriptional repressor CtBP, and also as a binding partner for other proteins including the cell cycle regulators retinoblastoma protein (Rb) and breast cancer 1 (BRCA1).
• It is ubiquitously expressed and localizes to the nucleus.
• RBBP8 is thought to modulate the functions in cell proliferation, transcriptional regulation and DNA repair.
• RBBP8 also plays a central role in the cell cycle checkpoint response to DNA double-stranded breaks (DSBs), with new evidence demonstrating that it controls the choice of DSB repair pathway.
• Applications:Suitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1-2ug/mlImmunohistochemistry (Formalin fixed paraffin embedded): 5ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Mouse Spleen Tissue Lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.