Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA.
In early 2009, a novel swine-origin influenza A (H1N1) virus (S-OIV) was identified in specimens obtained from patients in Mexico and the United States.
One of the less studied proteins encoded by, but not incorporated in, the influenza virus is the nonstructural protein (NS) 1.
NS1 counters cellular antiviral activities and acts as a virulence factor.
It can bind to double-stranded RNA and sequester it from 2-5' OAS, preventing the activation of the RNAse L, which normally acts to degrade RNA and prevent virus replication.
NS1 also binds to and inhibits the anti-viral protein kinase PKR.
This antibody is specific for the Swine-Origin H1N1 influenza NS1 and will not recognize the corresponding NS1 sequence from the seasonal H1N1 influenza (A/South Australia/51/2005 (H1N1)).
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes the Swine-Origin Influenza NS1.
Isotype：IgG
Calc Applications Abbrev：E
Immunogen：Synthetic peptide corresponding to the swine Influenza NS1.
