84-2111-57　Scavenger Receptor BI (Scavenger Receptor Class B Member 1, Scavenger Receptor Class B Type 1, Scavenging Receptor SR-BI, SCARB1, SRB1, SRBI, SR-BI, CD36 and LIMPII Analogous 1, CD36 Antigen-like 1, CD36L1, CLA1, CLA-1, Collagen Type I Receptor, MGC138242, Thrombospondin Receptor-like 1) 100ug　146450

特徴

• Scavenger receptor class B member 1 (SCARB1), also known as SR-BI, is part of the scavenger receptor superfamily, which is composed of many members with diverse structures, expression patterns, and functions.
• SCARB1 is a multi-ligand cell-surface receptor that mediates the selective uptake of lipid from HDL cholesterol into cells and is expressed in steroidogenic tissues in adult animals.
• Other ligands of SCARB1 include native, acetylated, or oxidized LDL and anionic phospholipids.
• SCARB1-deficient mice have elevated HDL levels and increased susceptibility to atherosclerosis on fat feeding, indicating its importance in the regulation of cholesterol homeostasis.
• Along with CLDN1, LDL-R, and the tetraspanin superfamily member CD81, SCARB1 has been reported to be an entry factor for the Hepatitis C virus.
• At least two isoforms of SCARB1 are known to exist.
• Applications:Suitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1-2ug/mlImmunohistochemistry (Formalin fixed paraffin embedded): 2.5ug/mlImmunofluorescence: 20ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Human Spleen Tissue Lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.