84-2111-55　CLDN1 (Claudin-1, Senescence-associated Epithelial Membrane Protein, CLD1, SEMP1, UNQ481/PRO944) 100ug　146448

特徴

• Claudin1 (CLDN1), a member of the claudin family, is an integral membrane protein and a component of tight junction strands.
• Tight junctions are specialized regions of cell to cell contact consisting of networking strands that act as a molecular gasket for preventing the leakage of ions, water, etc., between cells.
• They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity.
• Different tissues exhibit different Claudin composition and CLDN1 expression is often cell type and tissue dependent.
• Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
• CLDN1 and CLDN2 were found to be overexpressed in colonal cancer tissues and may be useful as tumor markers and targets for the treatment of colorectal cancer.
• Characterization of Claudins expression in human tumors can be an additional diagnostic tool.
• Recent studies show that CLDN1 has gastric tumor suppressive activity and is a direct transcriptional target of RUNX3.
• Along with SCARB1, LDL-R, and the tetraspanin superfamily member CD81, CLDN1 has been reported to be an entry factor for the Hepatitis C virus.
• Applications:Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1-2ug/mlImmunofluorescence: 20ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Human spleen Cell Lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.