84-2111-03　FNIP2, NT (Folliculin-interacting Protein 2, FNIP1-like Protein, O6-methylguanine-induced Apoptosis 1 Protein, FNIPL, KIAA1450, MAPO1) 100ug　146395

特徴

• FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene.
• Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors.
• Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation.
• FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship.
• Multiple isoforms of FNIP2 are known to exist.
• This antibody is predicted to not cross-react with FNIP1.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1-2ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Mouse Skeletal Muscle Tissue Lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.