84-2109-62　IRGM, NT (Immunity-related GTPase Family M Protein, Immunity-related GTPase Family M Protein 1, Interferon-inducible Protein 1, LPS-stimulated RAW 264.7 Macrophage Protein 47 Homolog, LRG-47, IFI1, IRGM1, LRG47) 100ug　146254

特徴

• Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells.
• It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components.
• Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease.
• In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48kD.
• Murine IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis.
• Human IRGM is also involved in autophagy and plays a role in the control of intracellular pathogens and in the reduction of intracellular bacillary load.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1-2ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Rat Brain Tissue Lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.