84-2109-52　LGI4, CT (Leucine-rich Repeat LGI Family Member 4, LGI1-like Protein 3, Leucine-rich Glioma-inactivated Protein 4, Lgil3) 100ug　146244

特徴

• The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar.
• The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors.
• LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms.
• Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE.
• However, the LGI4 gene is located in a region linked to benign familial infantile convulsions.
• Further study revealed that a GC-to-AT polymorphism was correlated with childhood absence epilepsy.
• Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development.
• Two isoforms of LGI4 are known to exist; this LGI4 antibody will recognize only the larger form.
• This LGI4 antibody is predicted to be specific to LGI4 and not recognize other LGI proteins.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1-2ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Rat Brain Tissue Lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.