84-2109-46　LGI3, ID (Leucine-rich Repeat LGI Family Member 3, LGI1-like Protein 4, Leucine-rich Glioma-inactivated Protein, LGIL4, UNQ8190/PRO23199) 100ug　146238

特徴

• The leucine-rich, glioma inactivated gene 3 (LGI3) is a member of the LGI family in which LGI1 is the exemplar.
• The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors.
• LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms.
• Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI3 have not been found to be associated with ADTLE.
• LGI3 expression is induced in rat astrocyte cultures by the amyloid beta (Ab) peptide and accumulated on neuronal plasma membranes of aged monkey brains and colocalized with Ab.
• Two isoforms of LGI3 are known to exist; this LGI3 antibody will recognize both.
• This LGI3 antibody is predicted to be specific to LGI3 and not recognize other LGI proteins.
• The observed higher molecular weight band may represent a post-translationally modified form of LGI3.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Human Brain Tissue Lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.