84-2108-18　TANK, NT (TRAF Family Member-associated NF-kappa-B Activator, TRAF-interacting Protein, ITRAF, I-TRAF, TRAF2) 100ug　146108

特徴

• TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction.
• Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kB.
• This activation of NF-kB occurs through an association with the kinases IKKe and TBK1.
• More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the IkB complex.
• This suggests that in addition to the possibility that TBK1 and IKKe activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-kB proteins.
• At least two isoforms of TANK are known to exist.
• Applications:Suitable for use in ELISA, Western Blot and Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.5-1ug/mlImmunocytochemistry: 2.5ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Daudi Cell Lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.