84-2108-16　BCL2A1, NT (Bcl-2-related Protein A1, Bcl-2-like Protein 5, Bcl2-L-5, Hemopoietic-specific Early Response Protein, Protein BFL-1, Protein GRS, BCL2L5, BFL1, GRS, HBPA1) 100ug　146106

特徴

• Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by caspase activation.
• Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes.
• One such member is multi-domain antiapoptotic protein Bfl-1, which is overexpressed in stomach and other cancers.
• Bfl-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation.
• It is upregulated in cisplatin-resistant human bladder tumors, suggesting that its expression may be important for cisplatin resistance and inhibition of apoptosis in cancer cells.
• At least two isoforms of Bfl-1 are known to exist.
• Applications:Suitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1-2ug/mlImmunofluorescence: 20ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Mouse Kidney Tissue Lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.