84-2107-58　MTOR (Serine/Threonine-protein Kinase mTOR, FK506-binding Protein 12-rapamycin Complex-associated Protein 1, FKBP12-rapamycin Complex-associated Protein, Mammalian Target of Rapamycin, mTOR, Mechanistic Target of Rapamycin, Rapamycin and FKBP12 Target 1, Rapamycin Target Protein 1, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, FLJ44809) 100ug　146047

特徴

• The mammalian Target of Rapamycin (TOR, also known as mTOR) is an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors.
• It was initially discovered as a kinase whose ability to stimulate T cell proliferation in response to IL-2 could be inhibited by the immunosuppressive drug rapamycin.
• Rapamycin inhibits TOR in other cell types resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation.
• TOR is normally associated with the regulatory proteins RAPTOR and GbetaL.
• Its downstream targets are thought to be the ribosomal protein S6 kinases and the eukaryotic initiation factor 4E binding proteins (4EBPs).
• Regulation of these protein families allows TOR to control protein biosynthesis.
• Applications:Suitable for use in ELISA, Western Blot and Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1-2ug/mlImmunocytochemistry: 2ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:L1210 Cell Lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.