84-2100-91　Caspr1 (Contactin-associated Protein-1, Neurexin-4, CNTNAP, CNTNAP1, p190) 100ug　145406

特徴

• CASPR1 (Contactin­ASsociated PRotein­1; also Neurexin­4 and p190) is a 180­195kD member of the neurexin family of proteins.
• It is expressed on both axons and dendrites of neurons, and likely serves the critical function of directing the movement of low MW contactin, AMPA receptors, and Na+ plus K+ channels to appropriate sites on the cell membrane.
• This indicates participation in key processes such as myelination and excitatory neurotransmission.
• Mature human CASRP1 is a 1365 amino acid (aa) type I transmembrane protein.
• It contains a 1264aa extracellular region (aa20­1283) plus an 80aa cytoplasmic domain.
• The extracellular region is highly modular, possessing one discoidin (carbohydrate­binding) domain (aa24­158), four laminin G­like domains (aa203­513, 813­956 and 1088­1250), two EGF­like domains (aa540­577 and 957­996) and one fibrinogen C­terminal globular regions (aa576­795).
• There is one potential alternative start site at Met507.
• Over aa20­1280, human CASPR1 shares 94% aa sequence identity with mouse CASPR1.
• Applications:Suitable for use in ELISA and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 5­15ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile ddH2O or PBS.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.