84-2100-85　ALDH3A1 (Aldehyde Dehydrogenase 3‑A1, ALDHIII, aldehyde Dehydrogenase, Dimeric NADP-preferring) 100ug　145382

特徴

• ALDH3A1 (Aldehyde dehydrogenase 3; also aldehyde dehydrogenase, dimeric NADP­preferring) is a 51­55kD, nuclear and cytosolic member of the ALDH3 family, ALDH superfamily of enzymes.
• It has widespread expression, being found in pancreatic acinar cells, corneal epithelium and stromal keratocytes, stem cells, and likely the epithelium of the jejunum.
• ALDH3A1 has many activities, including the detoxification of lipid peroxidation­derived medium chain (>5 carbon) aldehydes, the absorption of UV light in the cornea, acting as an antioxidant through the production of NADPH, and the extension of the cell cycle in expressing cells by reducing cyclin­dependent kinase activity.
• Notably, the critically important absorption of UVB light by ALDH3A1 in the cornea induces its aggregation and renders the molecule inactive as an enzyme.
• Human ALDH3A1 is 453 amino acids (aa) in length.
• It contains four acetylated lysines and a general catalytic region between aa5­447.
• There are potentially six splice variants, one of which shows a 130aa substitution for aa1­247.
• Over aa2­453, human ALDH3A1 shares 80% and 61% aa sequence identity with mouse ALDH3A1 asnd human ALDH3A2, respectively.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.25ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile ddH2O or PBS.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.