84-2100-65　VDAC1 (Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM) 100ug　145349

特徴

• The voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane is a small, abundant outer membrane pore-forming protein found in the outer membranes of all eukaryotic mitochondria.
• The VDAC protein is thought to form the major pathway for movement of adenine nucleotides through the outer membrane and to be the mitochondrial binding site for hexokinase and glycerol kinase.
• At low transmembrane voltage, VDAC is open for anions such as phosphate, chloride, and adenine nucleotides.
• At higher transmembrane voltage, VDAC functions as a selective channel for cations and uncharged molecules.
• These features make VDAC likely to play a role in mitochondrial energy metabolism.
• Huizing et al.
• studied by Northern and Western blot analyses the human tissue distribution of mitochondrial transmembrane metabolite carriers.
• They found that VDAC1 mRNA has a ubiquitous distribution, with most pronounced expression in heart, liver, and skeletal muscle, whereas the VDAC2 isoform appears to be expressed only in the heart.
• UniProt Number:P21796
• Gene ID:VDAC1
• Applications:Suitable for use in Western Blot, Immunohistochemistry (Paraffin and Frozen), and Immunocytochemistry.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Handling:Store at -20˚C for one year.
• After reconstitution, store at 4˚C for one month.
• Can also be aliquoted and stored frozen at -20˚C for long term
• Avoid repeated freezing and thawing.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.