84-2100-52　Trem1 (Triggering receptor expressed on myeloid cells 1) 100ug　145319

特徴

• Trem1, Triggering receptor expressed on myeloid cells-1, is encoded by Trem1 gene.
• The expression of Trem1 is in monocytes and neutrophils but not in lymphocytes, dendritic cells, or other cell types.
• Trem1 is a 30-kD glycoprotein that is reduced to 26 kD by deglycosylation, in agreement with the predicted molecular mass.
• The Trem1 gene which contains 4 exons maps to chromosome 6p21.1, within a TREM gene cluster and the mouse Trem1 gene maps to chromosome 17 in a region that shows homology of synteny to human chromosome 6.
• The expression of Trem1 is upregulated by stimulation with lipopolysaccharide (LPS), gram-negative bacteria, and fungi.
• Cross-linking of Trem1 on neutrophils induces interleukin-8 (IL8) and myeloperoxidase secretion, while cross-linking on monocytes induces not only secretion of IL8 but also of monocyte chemotactic protein-1 (MCP1, or SCYA2) and tumor necrosis factor (TNF); MCP1 and TNF secretion could be further upregulated by LPS-mediated priming.
• Trem1 engagement also induces upregulation of adhesion molecules (e.g., ITGB1) and costimulatory molecules (e.g., CD40).
• Trem1 is associated with DAP12 (TYROBP), a molecule frequently associated with activating receptors.
• UniProt Number:Q9JKE2
• Gene ID:TREM1
• Applications:Suitable for use in Western Blot, Immunohistochemistry (Paraffin and Frozen).
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Handling:Store at -20˚C for one year.
• After reconstitution, store at 4˚C for one month.
• Can also be aliquoted and stored frozen at -20˚C for long term
• Avoid repeated freezing and thawing.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.