Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene.
Survivin is a member of the inhibitor of apoptosis (IAP) family.
The survivin gene contains 4 exons.
The survivin gene is mapped to chromosome 17q25 by pulsed field gel electrophoresis and single- and 2-color FISH.
The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death.
The survivin protein is expressed highly in most human tumors and fetal tissue, but is completely absent in terminally differentiated cells.
UniProt Number:O15392
Gene ID:BIRC5
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry (Paraffin).
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Handling:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder. Each vial contains 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity：Recognizes human Survivin. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：E. coli-derived human Survivin recombinant protein (Position: M1-D142).
