SLC6A4(Solute carrier family 6, member 4), also known as SERT(serotonin transporter), is a monoamine transporter protein.
The SLC6A4 gene spans 31 kb and contains 14 exons.
This protein integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons.
This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner.
This protein is the target of many antidepressant medications, including those of the SSRI class.
It is a member of the sodium:neurotransmitter symporter family.
A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.
UniProt Number:P31652
Gene ID:SLC6A4
Applications:Suitable for use in Western Blot and Immunohistochemistry (Paraffin).
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Handling:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity：Recognizes mouse and rat SLC6A4. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Mo Rt
Immunogen：A synthetic peptide corresponding to a sequence at the N-terminal of rat SLC6A4, different from the related mouse sequence by one amino acid.
