84-2099-09　PTPN11/SHP-2 (Protein-tyrosine phosphatase 1D) 100ug　145110

特徴

• The tyrosine phosphatase Shp2 is recruited into tyrosine-kinase signalling pathways through binding of its two amino-terminal SH2 domains to specific phosphotyrosine motifs, concurrent with its re-localization and stimulation of phosphatase activity.
• Shp2 can potentiate signalling through the MAP-kinase pathway and is required during early mouse development for gastrulation.
• Shp2 is specifically required in mesenchyme cells of the progress zone (PZ), directly beneath the distal ectoderm of the limb bud.
• Rather than integrating proliferative signals, Shp2 probably exerts its effects on limb development by influencing cell shape, movement or adhesion.
• Furthermore, the branchial arches, which also use Fgfs during bud outgrowth, similarly require Shp2.
• Thus, Shp2 regulates phosphotyrosine-signalling events during the complex ectodermal-mesenchymal interactions that regulate mammalian budding morphogenesis.
• UniProt Number:Q06124
• Gene ID:PTPN11
• Applications:Suitable for use in Western Blot and Immunohistochemistry (Paraffin).
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Handling:Store at -20˚C for one year.
• After reconstitution, store at 4˚C for one month.
• Can also be aliquoted and stored frozen at -20˚C for long term
• Avoid repeated freezing and thawing.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.