84-2098-69　PIAS4 (Piasg, PIASY, FLJ12419, ZMIZ6, zinc finger, PIAS-gamma, MIZ-type containing 6, Protein inhibitor of activated STAT protein 4, Protein inhibitor of activated STAT protein gamma) 100ug　145054

特徴

• E3 SUMO-protein ligase PIAS4, also known as protein inhibitor of activated STAT protein 4 (PIAS4) or protein inhibitor of activated STAT protein gamma (PIASg or PIASy) is an enzyme that in humans is encoded by the PIRAS4 gene.
• This gene is mapped to 19p13.3.
• This gene plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway.
• It functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor.
• This gene involved in gene silencing.
• UniProt Number:Q8N2W9
• Gene ID:PIAS4
• Applications:Suitable for use in Western Blot.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Handling:Store at -20˚C for one year.
• After reconstitution, store at 4˚C for one month.
• Can also be aliquoted and stored frozen at -20˚C for long term
• Avoid repeated freezing and thawing.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.